| Arizona | Dennis DeConcini | Democratic | Retired: Republican Victory | Jon Kyl (Republican) 54% Sam Coppersmith (Democrat) 40% Scott Grainger (Libertarian) 7% |
| California | Dianne Feinstein | Democratic | Re-elected, 46.7% | Michael Huffington (Republican) 44.8% Elizabeth Barron (Peace and Freedom) 3% Richard Boddie (Libertarian) 2.1% Paul Meeuwenberg (AIP) 1.7% Barbara Blong (Green) 1.7% |
| Connecticut | Joe Lieberman | Democratic | Re-elected, 67% | Jerry Labriola (Republican) 31% Gary R. Garneau (Constitution) 2% |
| Delaware | William Roth | Republican | Re-elected, 55.8% | Charles Oberly (Democrat) 42.5% John C. Dierick (Libertarian) 1.7% |
| Florida | Connie Mack III | Republican | Re-elected, 70% | Hugh Rodham (Democrat) 30% |
| Hawaii | Daniel Akaka | Democratic | Re-elected, 71.8% | Maria Hustace (Republican) 24.2% Richard Rowland (Libertarian) 4% |
| Indiana | Richard Lugar | Republican | Re-elected, 67.4% | Jim Jontz (Democrat) 30.5% Barbara Bourland (Libertarian) 1.1% Mary Catherine Barton (NAP) 1% |
| Maine | George Mitchell | Democratic | Retired: Republican Victory | Olympia Snowe (Republican) 60.2% Thomas Andrews (Democrat) 36.4% Plato Truman (Independent) 3.4% |
| Maryland | Paul Sarbanes | Democratic | Re-elected, 59% | Bill Brock (Republican) 41% |
| Massachusetts | Edward M. Kennedy | Democratic | Re-elected, 58.1% | Mitt Romney (Republican) 41% Lauraleigh Dozier (Libertarian) 0.7% William A. Ferguson, Jr. (LaRouche Was Right) 0.2% |
| Michigan | Donald W. Riegle, Jr. | Democratic | Retired: Republican Victory | Spencer Abraham (Republican) 51.9% Bob Carr (Democrat) 42.7% Jon **** (Libertarian) 4.2% William Roundtree (Workers World Party) 0.7% Chris Wege (Natural Law) 0.5% |
| Minnesota | David Durenberger | Republican | Retired: Republican Victory | Rod Grams (Republican) 49.1% Ann Wynia (DFL) 44.1% Dean Barkley (Reform) 5.4% Candice E. Sjostrom (Grassroots) 0.9% Stephen Johnson (Natural Law) 0.3% Chris Wege (Socialist Workers) 0.1% |
| Mississippi | Trent Lott | Republican | Re-elected, 69% | Ken Harper (Democrat) 31% |
| Missouri | John Danforth | Republican | Retired: Republican Victory | John Ashcroft (Republican) 59.8% Alan Wheat (Democrat) 35.7% Bill Johnson (Libertarian) 4.6% |
| Montana | Conrad Burns | Republican | Re-elected, 62% | Jack Mudd (Democrat) 38% |
| Nebraska | Bob Kerrey | Democratic | Re-elected, 55% | Jan Stoney (Republican) 45% |
| Nevada | Richard H. Bryan | Democratic | Re-elected, 50.9% | Hal Furman (Republican) 41% Anna Nevenich (Independent) 1.8% Bob Days (Libertarian) 1.6% Neal A. Grasteit (Independent American) 1.4% |
| New Jersey | Frank Lautenberg | Democratic | Re-elected, 50.3% | Chuck Haytaian (Republican) 47% Michael P. Kelly (Keep America First) 0.7% Ben Grindlinger (Libertarian) 0.7% Richard J. Pezzullo (Conservative) 0.4% Andrea Lippi (Jobs, Property Rights) 0.3% George Patrick Predham (**** Drug Dealers) 0.2% Joanne Kuniansky (Socialist Workers Party) 0.2% Arlene Gold (Natural Law Party) 0.2% |
| New Mexico | Jeff Bingaman | Democratic | Re-elected, 54% | Colin McMillan (Republican) 46% |
| New York | Daniel Patrick Moynihan | Democratic | Re-elected, 55% | Bernadette Castro (Republican) 42.3% Henry F. Hewes (Right-to-Life) 1.8% Ismael Betancourt, Jr. (Independence Party of New York) 0.5% Norma Segal (Libertarian) 0.3% Naomi L. Craine (Socialist Workers) 0.3% |
| North Dakota | Kent Conrad | Democratic | Re-elected, 58% | Ben Clayburgh (Republican) 42% |
| Ohio | Howard Metzenbaum | Democratic | Retired: Republican Victory | Mike DeWine (Republican) 53% Joel Hyatt (Democrat) 39% Joseph Slovenec (Independent) 8% |
| Oklahoma1 | David L. Boren | Democratic | Resigned: Republican Victory | James Inhofe (Republican) 55.2% Dave McCurdy (Democrat) 40% Danny Corn (Independent) 4.8% |
| Pennsylvania2 | Harris Wofford | Democratic | Defeated, 46.9% | Rick Santorum (Republican) 49.4% Diane Blough (Patriot) 2% Donald C. Ernsberger (Libertarian) 1.7% |
| Rhode Island | John Chafee | Republican | Re-elected, 64% | Linda Kushner (Democrat) 36% |
| Tennessee | Jim Sasser | Democratic | Defeated, 43% | Bill Frist (Republican) 57% |
| Tennessee3 | Harlan Matthews | Democratic | Retired: Republican victory | Fred Thompson (Republican) 61% Jim Cooper (Democrat) 39% |
| Texas4 | Kay Bailey Hutchison | Republican | Re-elected, 60.8% | Richard W. Fisher (Democrat) 38.3% Pierre Blondeau (Libertarian) 0.8% |
| Utah | Orrin Hatch | Republican | Re-elected, 68.8% | Patrick Shea (Democrat) 28.3% Craig Oliver (Independent) 1.8% Gary R. Van Horn (American) 0.5% Nelson Gonzalez (Socialist Workers) 0.3% Lawrence Rey Topham (Independent American) 0.3% |
| Vermont | Jim Jeffords | Republican | Re-elected, 50.3% | Jan Backus (Democrat) 40.6% Gavin T. Mills (Independent) 5.9% Matthew S. Mulligan (Independent) 1.4% Bob Melamede (Grassroots) 0.7% Jerry Levy (Liberty Union) 0.6% Joseph Victor Pardo (Natural Law Party) 0.3% |
| Virginia | Chuck Robb | Democratic | Re-elected, 46% | Oliver North (Republican) 43% J. Marshall Coleman (Independent) 11% |
| Washington | Slade Gorton | Republican | Re-elected, 56% | Ron Sims (Democrat) 44% |
| West Virginia | Robert Byrd | Democratic | Re-elected, 69% | Stanley L. Klos (Republican) 31% |
| Wisconsin | Herb Kohl | Democratic | Re-elected, 58% | Robert Welch (Republican) 40.7% James Dean (Libertarian) 1% |
| Wyoming | Malcolm Wallop | Republican | Retired: Republican Victory | Craig Thomas (Republican) 58.9% Mike Sullivan (Democrat) 39.3% Craig McCune (Libertarian) 1.8% |